Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.

@article{Duvall2006MaintenanceOH,
  title={Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection.},
  author={Melody G Duvall and Assan Jaye and Tao Dong and Jason M. Brenchley and Abraham Alabi and David J. Jeffries and Marianne van der Sande and Toyin Omotayo Togun and Samuel J. McConkey and Daniel C. Douek and Andrew J McMichael and Hilton C. Whittle and Richard A. Koup and Sarah L Rowland-Jones},
  journal={Journal of immunology},
  year={2006},
  volume={176 11},
  pages={6973-81}
}
Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation assays, we show that HIV-specific CD4+ T cells from HIV-2-infected individuals maintained proliferative… CONTINUE READING