Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial.

@article{Hanauer2002MaintenanceIF,
  title={Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial.},
  author={S B Hanauer and Brian G Feagan and Gary R. Lichtenstein and Lloyd F Mayer and Stefan Schreiber and Jean Fr{\'e}d{\'e}ric Colombel and Daniel Rachmilewitz and D. Wolf and Allan D. Olson and Weihang Bao and P. R. Rutgeerts},
  journal={Lancet},
  year={2002},
  volume={359 9317},
  pages={1541-9}
}
BACKGROUND We did a randomised controlled trial to assess the benefit of maintenance infliximab therapy in patients with active Crohn's disease who respond to a single infusion of infliximab. METHODS 573 patients with a score of at least 220 on the Crohn's disease activity index (CDAI) received a 5 mg/kg intravenous infusion of infliximab at week 0. After assessment of response at week 2, patients were randomly assigned repeat infusions of placebo at weeks 2 and 6 and then every 8 weeks… CONTINUE READING
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