Maintenance and repair of the bronchiolar epithelium.

  title={Maintenance and repair of the bronchiolar epithelium.},
  author={Barry R Stripp and Susan D Reynolds},
  journal={Proceedings of the American Thoracic Society},
  volume={5 3},
Bronchioles of the distal conducting airway are lined by a simple epithelium composed primarily of nonciliated secretory (Clara) cells and ciliated cells. These cells are long-lived in the normal lung; renewal is mediated by cells that constitute a nonclassical stem cell hierarchy. Within this type of hierarchy, facultative progenitor cells are responsible for normal epithelial maintenance and rare adult tissue-specific stem cells are activated only in response to depletion of the facultative… CONTINUE READING