Maintaining the integrity of human immunodeficiency virus sequence databases.

  title={Maintaining the integrity of human immunodeficiency virus sequence databases.},
  author={Gerald H. Learn and Bette T Korber and Brad Foley and Beatrice H. Hahn and Steven M. Wolinsky and James I. Mullins},
  journal={Journal of virology},
  volume={70 8},
Human immunodeficiency virus type 1 (HIV-1) sequences are accumulating in the literature at a rapid pace. For this ever-expanding resource to be maximally useful, it is critical that researchers strive to maintain a high level of quality assurance, both in experimental design and conduct and in analyses. Here we present detailed analyses of problematic sets of HIV-1 sequences in the database that include sequence anomalies suggestive of mislabeling or sample contamination problems. These data… CONTINUE READING


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