Maintaining replication fork integrity in UV-irradiated Escherichia coli cells.

@article{Rudolph2008MaintainingRF,
  title={Maintaining replication fork integrity in UV-irradiated Escherichia coli cells.},
  author={Christian J Rudolph and A. Louise Upton and R. G. Lloyd},
  journal={DNA repair},
  year={2008},
  volume={7 9},
  pages={1589-602}
}
In dividing cells, the stalling of replication fork complexes by impediments to DNA unwinding or by template imperfections that block synthesis by the polymerase subunits is a serious threat to genomic integrity and cell viability. What happens to stalled forks depends on the nature of the offending obstacle. In UV-irradiated Escherichia coli cells DNA synthesis is delayed for a considerable period, during which forks undergo extensive processing before replication can resume. Thus, restart… CONTINUE READING
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Spatial and temporal organization of replicating Escherichia coli chromosomes

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