Maintaining immunological tolerance with Foxp3

@article{Mays2007MaintainingIT,
  title={Maintaining immunological tolerance with Foxp3},
  author={Lauren E. Mays and Youhai H Chen},
  journal={Cell Research},
  year={2007},
  volume={17},
  pages={904-918}
}
  • Lauren E. Mays, Youhai H Chen
  • Published in Cell Research 2007
  • Biology, Medicine
  • Central tolerance in the thymus is the primary mechanism for deleting autoreactive T cells. Despite this, escape of self-reactive T lymphocytes into the periphery reveals the threat of autoimmunity. To compensate for its imperfection, the thymus also produces a naturally occurring subset of Foxp3+ CD4+ CD25+ regulatory T cells with suppressive function, capable of controlling autoreactive cells. Foxp3 (forkhead box P3), the lineage-specific marker for this subset of cells, is crucial to their… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Figures and Topics from this paper.

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 12 CITATIONS

    Molecular biology of atherosclerosis.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Adaptive T cell immune responses and atherogenesis.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 104 REFERENCES