Maintaining good hearing: calorie restriction, Sirt3, and glutathione.

  title={Maintaining good hearing: calorie restriction, Sirt3, and glutathione.},
  author={Chul Han and Shinichi Someya},
  journal={Experimental gerontology},
  volume={48 10},
Reducing calorie intake extends the lifespan of a variety of experimental models and delays progression of age-related hearing loss (AHL). AHL is a common feature of aging and is characterized by age-related decline of hearing associated with loss of sensory hair cells, spiral ganglion neurons, and/or stria vascularis degeneration in the cochlea. Sirtuins are a family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms and have emerged as broad regulators of cellular fate. Our… CONTINUE READING
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