Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel.

@article{Liao2013MaintainingFI,
  title={Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel.},
  author={Sophia W Liao and Jeffrey S Rawson and Keiko Omori and Kohei Ishiyama and Davoud Mozhdehi and Alina R Oancea and Taihei Ito and Zhibin Guan and Yoko S Mullen},
  journal={Biomaterials},
  year={2013},
  volume={34 16},
  pages={3984-91}
}
Islet transplantation offers a promising treatment for type 1 diabetes (T1D). However, a major hurdle in this treatment is the rapid loss of functional islets during culture and after transplantation. The liver site, currently utilized for transplantation, is suboptimal for achieving long-term insulin independence due to a rapid islet loss followed by a chronic decline in islet function after transplantation. Herein, we report a synthetic saccharide-peptide (SP) hydrogel that allows suspending… CONTINUE READING