Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats.

@article{Loring2010MaintainingET,
  title={Maintaining end-expiratory transpulmonary pressure prevents worsening of ventilator-induced lung injury caused by chest wall constriction in surfactant-depleted rats.},
  author={Stephen H Loring and Matteo Pecchiari and Patrizia Della Valle and Ario Monaco and Guendalina Gentile and Emanuela D'angelo},
  journal={Critical care medicine},
  year={2010},
  volume={38 12},
  pages={2358-64}
}
OBJECTIVE To see whether in acute lung injury 1) compression of the lungs caused by thoracoabdominal constriction degrades lung function and worsens ventilator-induced lung injury; and 2) maintaining end-expiratory transpulmonary pressure by increasing positive end-expiratory pressure reduces the deleterious effects of chest wall constriction. DESIGN Experimental study in rats. SETTING Physiology laboratory. INTERVENTIONS Acute lung injury was induced in three groups of nine rats by… CONTINUE READING