Maintaining embryonic stem cell pluripotency with Wnt signaling.

  title={Maintaining embryonic stem cell pluripotency with Wnt signaling.},
  author={Sergei Y Sokol},
  volume={138 20},
Wnt signaling pathways control lineage specification in vertebrate embryos and regulate pluripotency in embryonic stem (ES) cells, but how the balance between progenitor self-renewal and differentiation is achieved during axis specification and tissue patterning remains highly controversial. The context- and stage-specific effects of the different Wnt pathways produce complex and sometimes opposite outcomes that help to generate embryonic cell diversity. Although the results of recent studies… CONTINUE READING
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