Maintaining differentiated cellular identity

  title={Maintaining differentiated cellular identity},
  author={Johan Holmberg and Thomas Perlmann},
  journal={Nature Reviews Genetics},
Various studies have demonstrated that somatic differentiated cells can be reprogrammed into other differentiated states or into pluripotency, thus showing that the differentiated cellular state is not irreversible. These findings have generated intense interest in the process of reprogramming and in mechanisms that govern the pluripotent state. However, the realization that differentiated cells can be triggered to switch to considerably different lineages also emphasizes that we need to… CONTINUE READING
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