Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk.

  title={Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk.},
  author={Ameen A. Salahudeen and Richard K. Bruick},
  journal={Annals of the New York Academy of Sciences},
Though iron and oxygen are required to sustain essential biological processes, an excess of either can result in oxidative stress. Therefore, mammals tightly regulate cellular and systemic iron and oxygen homeostasis. At the cellular level, the hypoxia-inducible transcription factors (HIFs) are key mediators of oxygen homeostasis through their regulation of genes involved in anaerobic metabolism and oxygen delivery, among others. Iron regulatory proteins (IRPs) largely govern cellular iron… CONTINUE READING


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