Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade.

@article{Nielsen2007MaintainedET,
  title={Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade.},
  author={Jakob Nielsen and T Chong-Suk KwoN and J\orgen Fr\okiaer and Mark A. Knepper and S\oren Nors Nielsen},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 1},
  pages={F382-94}
}
Aldosterone induces redistribution of epithelial sodium channel (ENaC) to the apical plasma membrane from intracellular vesicles in renal connecting tubule (CNT) and cortical collecting duct (CCD). The role of the classical mineralocorticoid receptor (MR) in ENaC trafficking is still debated. We examined whether the MR antagonist spironolactone affects ENaC regulation in the kidney cortex of aldosterone-infused rats. Aldosterone infusion for 7 days resulted in a plasma aldosterone concentration… CONTINUE READING

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