Main interactions and influences of the chromatographic parameters in HILIC separations.

@article{Greco2013MainIA,
  title={Main interactions and influences of the chromatographic parameters in HILIC separations.},
  author={Giorgia Greco and Thomas Letzel},
  journal={Journal of chromatographic science},
  year={2013},
  volume={51 7},
  pages={684-93}
}
Hydrophilic interaction liquid chromatography (HILIC) is a popular technique for the separation of polar compounds, which are poorly retained by reversed-phase liquid chromatography. Despite the versatility and the potentiality of this technique, many analysts still feel uncomfortable when approaching it. The HILIC retention mechanism is not completely elucidated and the availability of many different stationary phases may be confusing during method development. Understanding the principles… CONTINUE READING

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