Main drug- and carcinogen-metabolizing enzyme systems in human non-small cell lung cancer and peritumoral tissues.

@article{Toussaint1993MainDA,
  title={Main drug- and carcinogen-metabolizing enzyme systems in human non-small cell lung cancer and peritumoral tissues.},
  author={Caroline Toussaint and Nicolas Albin and Liliane Massaad and Dominique H Grunenwald and Orlando Parise and Jackie Morizet and Alain J. Gouyette and Guy G. Chabot},
  journal={Cancer research},
  year={1993},
  volume={53 19},
  pages={4608-12}
}
To better understand the importance of drug-metabolizing enzymes in carcinogenesis and anticancer drug sensitivity of human non-small cell lung cancer, we studied the main drug-metabolizing enzyme systems in both lung tumors and their corresponding nontumoral lung tissues in 12 patients. The following enzymes were assayed by Western blot analysis: cytochromes P-450 (1A1/A2, 2B1/B2, 2C8-10, 2E1, 3A4); epoxide hydrolase; and glutathione S-transferase isoenzymes (GST-alpha, -mu, and -pi). The… CONTINUE READING

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