Mahanine, a DNA minor groove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and -NH functional groups.

@article{Samanta2013MahanineAD,
  title={Mahanine, a DNA minor groove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and -NH functional groups.},
  author={Suman Kumar Samanta and Devawati Dutta and Sarita Roy and Kaushik Bhattacharya and Sayantani Sarkar and Anjan Kr Dasgupta and Bikas Chandra Pal and Chhabinath Mandal and Chitra Mandal},
  journal={Journal of medicinal chemistry},
  year={2013},
  volume={56 14},
  pages={5709-21}
}
Mahanine, a carbazole alkaloid is a potent anticancer molecule. To recognize the structure-activity correlation, mahanine was chemically modified. Antiproliferative activity of these derivatives was determined in 19 cancer cell lines from 7 different origins. Mahanine showed enhanced apoptosis compared to dehydroxy-mahanine-treated cells, indicating significant contribution of the C-7-OH group. O-Methylated-mahanine and N-methylated dehydroxy-mahanine-treated cells exhibited apoptosis only at… CONTINUE READING

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