Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.

@article{Lee2009MagnololIA,
  title={Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.},
  author={Dae-Hee Lee and Miroslaw-Jerzy Szczepanski and Yong Joo Lee},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={106 6},
  pages={1113-22}
}
We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb Magnolia officinalis, induced apoptotic cell death in a dose- and time-dependent manner. A sustained inhibition of the major survival signal, Akt, occurred in magnolol-treated cells. Treatment of PC-3 cells with an apoptosis-inducing concentration of magnolol (60 microM) resulted in a rapid decrease in the level of phosphorylated Akt leading… CONTINUE READING

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