Magnolol induces apoptosis in vascular smooth muscle

  title={Magnolol induces apoptosis in vascular smooth muscle},
  author={Jiun-Han Chen and C Wu and George Hsiao and M Yen},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Magnolol, an active component extracted from Magnolia officinalis, has various pharmacological effects, including potent antioxidant activity. In the present study, we investigated the effect of magnolol on apoptosis in rat vascular smooth muscle cells (VSMCs), using terminal-deoxynucleotidyl-transferase-mediated deoxyuridine triphosphate nick end labelling (TUNEL) and flow cytometric analysis. Magnolol (5–20 µM) concentration-dependently induced significant VSMC apoptosis, this effect being… CONTINUE READING


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