Magnocellular vasopressinergic neurons in explant cultures are rescued from cell death by ciliary neurotrophic factor and leukemia inhibiting factor

@article{Vutskits1998MagnocellularVN,
  title={Magnocellular vasopressinergic neurons in explant cultures are rescued from cell death by ciliary neurotrophic factor and leukemia inhibiting factor},
  author={Laszlo Vutskits and Viktor Bartanusz and Michael Schulz and Jozsef Z. Kiss},
  journal={Neuroscience},
  year={1998},
  volume={87},
  pages={571-582}
}
Selective death of magnocellular vasopressinergic neurons in the hypothalamus has been reported in cases of hereditary and idiopathic diabetes insipidus and after experimental lesions of the hypothalamo-neurohypophyseal pathway. To identify trophic factors that promote survival of these neurons, an in vitro model system was established in which organotypic cultures of the rat hypothalamic paraventricular nucleus were maintained in chemically-defined medium. We observe that the majority of… CONTINUE READING
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