Magnitude of TGF-initiated nephron-nephron interactions is increased in SHR.

  title={Magnitude of TGF-initiated nephron-nephron interactions is increased in SHR.},
  author={Yuming Chen and K. P. Yip and Donald J. Marsh and N.-H. Holstein-Rathlou},
  journal={The American journal of physiology},
  volume={269 2 Pt 2},
We compared the tubuloglomerular feedback (TGF)-initiated nephron-nephron interaction in spontaneously hypertensive rats (SHR) and normotensive Sprague-Dawley (SD) rats. Interaction strength was assessed by measuring stop-flow pressure (delta SFP) responses in pairs of nephrons, where only one nephron of the pair was microperfused. The vascular connection was determined from casts of the nephrons and vessels; length of arteriolar separation between the two glomeruli was measured on the casts… CONTINUE READING


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