Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation.

@article{Birukova2008MagnitudedependentEO,
  title={Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation.},
  author={Anna A Birukova and Nurgul K Moldobaeva and Junjie Xing and Konstantin G Birukov},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 4},
  pages={L612-23}
}
Mechanical ventilation at high tidal volumes compromises the blood-gas barrier and increases lung vascular permeability, which may lead to ventilator-induced lung injury and pulmonary edema. Using pulmonary endothelial cell (ECs) exposed to physiologically [5% cyclic stretch (CS)] and pathologically (18% CS) relevant magnitudes of CS, we evaluated the potential protective effects of hepatocyte growth factor (HGF) on EC barrier dysfunction induced by CS and vascular endothelial growth factor… CONTINUE READING