Magnitude and quality of vaccine-elicited T-cell responses in the control of immunodeficiency virus replication in rhesus monkeys.

@article{Sun2008MagnitudeAQ,
  title={Magnitude and quality of vaccine-elicited T-cell responses in the control of immunodeficiency virus replication in rhesus monkeys.},
  author={Yue Sun and Sampa Santra and Joern E Schmitz and Mario Roederer and Norman L. Letvin},
  journal={Journal of virology},
  year={2008},
  volume={82 17},
  pages={8812-9}
}
While a diversity of immunogens that elicit qualitatively different cellular immune responses are being assessed in clinical human immunodeficiency virus vaccine trials, the consequences of those varied responses for viral control remain poorly understood. In the present study, we evaluated the induction of virus-specific T-cell responses in rhesus monkeys using a series of diverse vaccine vectors. We assessed both the magnitude and the functional profile of the virus-specific CD8(+) T cells by… CONTINUE READING

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The impact of a boosting immunogen on the differentiation of secondary memory CD8 T cells

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