Magnetization transfer ratio evolution with demyelination and remyelination in multiple sclerosis lesions.

@article{Chen2008MagnetizationTR,
  title={Magnetization transfer ratio evolution with demyelination and remyelination in multiple sclerosis lesions.},
  author={Jacqueline Tien-Hsiang Chen and D. Louis Collins and Harold L. Atkins and M. S. Freedman and Douglas L. Arnold},
  journal={Annals of neurology},
  year={2008},
  volume={63 2},
  pages={254-62}
}
OBJECTIVE To assess demyelination and remyelination in vivo in acute gadolinium (Gd)-enhancing lesions of multiple sclerosis (MS). METHODS We measured significant changes in magnetization transfer ratio (MTR) consistent with demyelination and remyelination of individual lesion voxels, as well as the mean normalized MTR over all lesion voxels during and after contrast enhancement, in MS patients participating in a 3-year Canadian trial assessing immunoablation and autologous stem cell… CONTINUE READING

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