Magnetic targeting of nanoparticles across the intact blood-brain barrier.

  title={Magnetic targeting of nanoparticles across the intact blood-brain barrier.},
  author={Seong Deok Kong and Jisook Lee and Srinivasan Ramachandran and Brian P. Eliceiri and Veronica I Shubayev and Ratnesh Lal and Sungho Jin},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={164 1},
Delivery of therapeutic or diagnostic agents across an intact blood-brain barrier (BBB) remains a major challenge. Here we demonstrate in a mouse model that magnetic nanoparticles (MNPs) can cross the normal BBB when subjected to an external magnetic field. Following a systemic administration, an applied external magnetic field mediates the ability of MNPs to permeate the BBB and accumulate in a perivascular zone of the brain parenchyma. Direct tracking and localization inside endothelial cells… CONTINUE READING
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