Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.

  title={Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.},
  author={Lidia S. Szczepaniak and Pamela Nurenberg and David Leonard and Jeffrey D. Browning and Jason S. Reingold and Scott M. Grundy and Helen H. Hobbs and Robert L. Dobbins},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={288 2},
Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the criteria used to diagnose the disorder remain poorly defined. Localized proton magnetic resonance spectroscopy (MRS) accurately measures hepatic triglyceride content (HTGC) but has been used only in small research studies. Here, MRS was used to analyze the distribution of HTGC in 2,349 participants from the Dallas Heart Study (DHS). The reproducibility of the procedure was validated by showing that duplicate HTGC… 

Figures and Tables from this paper

Comparison of Liver Fat Indices for the Diagnosis of Hepatic Steatosis and Insulin Resistance

The tested indices offer modest efficacy to detect steatosis and cannot substitute for fat quantification by 1H-MRS, however, all indices might serve as surrogate parameters for liver fat content and also as rough clinical estimates of abnormal insulin sensitivity and secretion.

Ultrasonography to Quantify Hepatic Fat Content: Validation by 1H Magnetic Resonance Spectroscopy

This validation study shows that a combination of computer‐assessed ultrasound measures from routine ultrasound images can be used to quantitatively assess hepatic fat content and reveals a significant advantage of the quantitative model in predicting hepaticfat content.

Validity of ultrasonography to assess hepatic steatosis compared to magnetic resonance spectroscopy as a criterion method in older adults

Ultrasound is a valid method for detecting the presence or absence of hepatic steatosis in older adults and can be used as an alternative tool in both clinical investigations and epidemiological studies, when other imaging techniques are not feasible.

Sonographic quantification of a Hepato-Renal Index for the assessment of hepatic steatosis in comparison with 3T proton magnetic resonance spectroscopy

This study shows that the Sonographic Hepato-Renal Index is a valid, simple, reliable, and cost-effective screening tool for the identification, assessment, and quantification of hepatic steatosis in the general population.

Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease

I HTG accumulation is strongly associated with adipose tissue insulin resistance (IR), supporting the current theory of lipotoxicity as a driver of IHTG accumulation.

Noninvasive assessment of hepatic lipid composition: Advancing understanding and management of fatty liver disorders

The 1H‐MRS method provides for rapid, qualitative assessment of lipid composition and produces results that are consistent with biopsy‐based approaches demonstrating that relative hepatic lipid saturation increases and polyunsaturation decreases with obesity.

Prevalence of Fatty Liver Disease and Hepatic Iron Overload in a Northeastern German Population by Using Quantitative MR Imaging.

In a white German population, the prevalence of fatty liver diseases and liver iron overload is 42.2% and 17.4% respectively, whereas liver fat is associated with predictors related to the metabolic syndrome, liver iron content is mainly associated with mean serum corpuscular hemoglobin.

External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals.

FLI and LAP may be used to identify patients with hepatic steatosis clinically or for research purposes but could not quantitatively predict liver fat content.



Quantification of liver fat using magnetic resonance spectroscopy.

Noninvasive in vivo quantitative assessment of fat content in human liver.

Fatty Infiltration of the Liver: Quantification by 1H Localized Magnetic Resonance Spectroscopy and Comparison with Computed Tomography

The authors evaluated the degree of fatty infiltration of the liver in subjects with diffuse liver steatosis using image-guided 1H localized MR spectroscopy and correlated the magnetic resonance-determined fat fraction with the computed tomography liver/spleen density ratio and histologic evaluation.

Liver pathology and the metabolic syndrome X in severe obesity.

It is concluded that the metabolic syndrome via impaired glucose tolerance is strongly correlated with steatosis, fibrosis, and cirrhosis of the liver.

Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis

The results indicate that determination of the fat volume fraction in steatotic liver can be achieved noninvasively with MR spectroscopy.

Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo.

This study demonstrates for the first time that noninvasive in vivo 1H MRS measurement of intracellular TG, including that within myocytes, is feasible at 1.5-T field strengths and is comparable in accuracy to biochemical measurement.

Liver steatosis and its relation to plasma haemostatic factors in apparently healthy men--role of the metabolic syndrome.

Results indicate that liver steatosis correlates specifically with increased PAI-1, F-VIIc and decreased t-PA levels, and suggest that such a relation is largely mediated by concomitant alterations in plasma triglyceride and insulin concentrations.

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome.

It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

Fat accumulation in the liver is, independent of body mass index and intraabdominal and overall obesity, characterized by several features of insulin resistance in normal weight and moderately overweight subjects.

Prevalence of and Risk Factors for Hepatic Steatosis in Northern Italy

Data indicate that obesity plays a greater role than excessive alcohol intake in inducing fatty liver, and the relative roles of obesity and alcohol abuse, alone and in combination, in inducing steatosis are explored.