Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T

@article{Joshi2012MagneticRS,
  title={Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T},
  author={Gagan Joshi and Joseph Biederman and Janet Wozniak and Rachel L. Goldin and Dave Crowley and Stephannie L. Furtak and Scott E. Lukas and Atilla G{\"o}nenç},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2012},
  volume={263},
  pages={379-384}
}
The pilot study aimed at examining the neural glutamatergic activity in autism. Seven adolescent males (mean age: 14 ± 1.8; age range: 12–17 years) with intact intellectual capacity (mean IQ: 108 ± 14.26; IQ range: 85–127) suffering from autistic disorder and an equal number of age- and sex-matched healthy controls underwent a two-dimensional magnetic resonance spectroscopy scan at 4T. Results indicated significantly high glutamate (Glu) levels in the anterior cingulate cortex of autistic… CONTINUE READING