Magnetic resonance spectroscopy of cellular lipid extracts from sensitive, resistant and reverting K562 cells and flow cytometry for investigating the P-glycoprotein function in resistance reversion.

@article{Moyec2000MagneticRS,
  title={Magnetic resonance spectroscopy of cellular lipid extracts from sensitive, resistant and reverting K562 cells and flow cytometry for investigating the P-glycoprotein function in resistance reversion.},
  author={Laurence Le Moyec and Ollivier Legrand and Val{\'e}ry Larue and Mitsuyuki Kawakami and Jean Paul Marie and Fabian Calvo and Edith Hantz and Eliane Taillandier},
  journal={NMR in biomedicine},
  year={2000},
  volume={13 2},
  pages={92-101}
}
The proton NMR spectra of K562 cells contain resonances of lipids. When these cells acquire multidrug resistance phenotype, the NMR lipid signals are modified and partially recovered when the resistance is reversed. The goals of the present study are to elucidate the mechanism of the resistance phenotype reversion and to investigate the possible origin of lipid signals detected in whole cells with proton NMR spectroscopy. Therefore, the K562 drug-sensitive cell line, its adriamycin resistant… CONTINUE READING
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