Magnetic resonance imaging visualization of targeted cells by the internalization of supramolecular adducts formed between avidin and biotinylated Gd3+ chelates

@article{Crich2004MagneticRI,
  title={Magnetic resonance imaging visualization of targeted cells by the internalization of supramolecular adducts formed between avidin and biotinylated Gd3+ chelates},
  author={Simonetta Geninatti Crich and Alessandro Barge and Elisa Battistini and Claudia Cabella and Sara Coluccia and Dario Longo and Valentina Mainero and Guido Tarone and Silvio Aime},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2004},
  volume={10},
  pages={78-86}
}
The high binding affinity between avidin and biotin has been exploited to develop a procedure for magnetic resonance imaging (MRI) visualization of target cells. SHIN3 and PANC1 tumor cell lines have been used as target cells because they possess on their membranes galactosyl receptors able to bind avidin molecules. Avidin–Gd chelate adducts have been built by using two Gd complexes containing one (Gd-I) and two (Gd-II) biotin residues, respectively. The relaxivities of such supramolecular… CONTINUE READING

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European journal of radiology • 1996
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