Magnetic resonance imaging of differential gray versus white matter injury following a mild or moderate hypoxic-ischemic insult in neonatal rats.

@article{Qiao2004MagneticRI,
  title={Magnetic resonance imaging of differential gray versus white matter injury following a mild or moderate hypoxic-ischemic insult in neonatal rats.},
  author={Min Qiao and Shuzhen Meng and Kathryn Scobie and Tadeusz Foniok and Ursula I. Tuor},
  journal={Neuroscience letters},
  year={2004},
  volume={368 3},
  pages={332-6}
}
Selective white matter injury in the pre-mature infants suggests it has a greater susceptibility to hypoxia-ischemia. To investigate whether white matter injury would predominate following a mild hypoxic-ischemic insult, 7-day-old rats underwent either mild or moderate hypoxia-ischemia and magnetic resonance imaging 24 h later. Mild and moderate hypoxia-ischemia were produced by unilateral carotid artery occlusion plus exposure to hypoxia for either 45-50 or 90 min at ambient temperatures of 34… CONTINUE READING