Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature.

  title={Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature.},
  author={Patrice P{\'e}ran and A Cherubini and Francesca Assogna and Fabrizio Piras and Carlo Cosimo Quattrocchi and Antonella Peppe and Pierre Celsis and Olivier Rascol and Jean-François D{\'e}monet and Alessandro Stefani and Mariangela Pierantozzi and Francesco E Pontieri and Carlo Caltagirone and Gianfranco Spalletta and Umberto Sabatini},
  journal={Brain : a journal of neurology},
  volume={133 11},
One objective of modern neuroimaging is to identify markers that can aid in diagnosis, disease progression monitoring and long-term drug impact analysis. In this study, Parkinson-associated physiopathological modifications were characterized in six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive to complementary tissue characteristics (i.e. volume atrophy, iron deposition and microstructural damage). Thirty patients with Parkinson's… CONTINUE READING
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