Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results.

@article{Barkhof2007MagneticRI,
  title={Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results.},
  author={Frederik Barkhof and Chris H. Polman and Ernst-Wilhelm Radue and Ludwig Kappos and Mark Steven Freedman and Gilles Edan and H. P. Hartung and David H. Miller and Xavier Montalban and Peter A. Poppe and Marlieke de Vos and Fatiha Lasri and Lars Bauer and Susanne Dahms and Klaus Wagner and Christoph Pohl and Rupert Sandbrink},
  journal={Archives of neurology},
  year={2007},
  volume={64 9},
  pages={
          1292-8
        }
}
BACKGROUND In the Betaseron/Betaferon in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT) study, interferon beta-1b delayed conversion to multiple sclerosis in patients with a first clinical event and at least 2 clinically silent brain magnetic resonance imaging (MRI) lesions. OBJECTIVE To examine detailed MRI findings from the first 2 years of this trial. DESIGN Double-blind, placebo-controlled, randomized, parallel-group, multicenter, phase 3 study. SETTING Ninety-eight… Expand
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49 Citations
Background Citations
10
Methods Citations
5
Results Citations
2

Paper Mentions

Interventional Clinical Trial
BENEFIT Study (Betaferon® / Betaseron® in Newly Emerging Multiple Sclerosis for Initial Treatment) and BENEFIT Follow-up Study
This study will primarily compare the long-term effects of an early and continued treatment with Betaferon/Betaseron (patients who were treated with active medication during the… Expand
ConditionsMultiple Sclerosis
InterventionDrug
Bayer
August 2002 - May 2008

49 Citations

Citation Type

Citation Type

Efficacy of subcutaneous interferon β-1a on MRI outcomes in a randomised controlled trial of patients with clinically isolated syndromes
TLDR
Both subcutaneous IFN β-1a 44 µg regimens improved MRI outcomes versus placebo, with the three times a week regimen having a more pronounced effect than once a week dosing. Expand
Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial
TLDR
Effects on the rate of conversion to CDMS and the favourable long-term safety and tolerability profile support early initiation of treatment with interferon beta-1b, although a delay in treatment by up to 2 years did not affect long- term disability outcomes. Expand
Magnetic resonance imaging predictors of conversion to multiple sclerosis in the BENEFIT study.
TLDR
The modified Barkhof criteria showed moderate predictive value for conversion to CDMS, although all patients had received interferon beta-1b therapy for at least 1 year, and the predictive value was unaffected by treatment intervention. Expand
MRI outcomes with cladribine tablets for multiple sclerosis in the CLARITY study
TLDR
MRI-measured disease activity was greatly reduced by both doses of cladribine tablets, with consistent effect across clinically relevant patient populations, and these findings add to the scientific understanding of the neurological impact of this therapeutic modality in patients with RRMS. Expand
Interferon beta-1b reduces black holes in a randomised trial of clinically isolated syndrome
TLDR
Although the rate of lesions that converted to PBH showed no significant differences between groups, the numbers of PBHs per patient out of new lesions was significantly lower in IFNB-1b patients compared to patients on placebo. Expand
Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis
TLDR
There is growing evidence from clinical trials on relapsing-remitting MS and clinically isolated syndromes suggestive of MS that IFNβ-1b reduces the frequency and severity of relapses and the development of new and active brain lesions as assessed by magnetic resonance imaging. Expand
Interferon-β-1b
TLDR
Interferon-β-1b is a well established, first-line, disease-modifying therapy that has demonstrated efficacy in newly emerging MS, RRMS and SPMS with superimposed relapse in well designed clinical trials, and has a generally manageable tolerability profile, with no unexpected adverse events after many years of follow-up. Expand
MRI monitoring of immunomodulation in relapse-onset multiple sclerosis trials
TLDR
Up-to-date recommendations for scan acquisition, image analysis, outcome-measure definition and standards of reporting are provided and safety considerations in the use of MRI in MS trials are addressed. Expand
Subcutaneous interferon β-1a in the treatment of clinically isolated syndromes: 3-year and 5-year results of the phase III dosing frequency-blind multicentre REFLEXION study
TLDR
Over 5 years in patients presenting with an FCDE, early sc IFN β-1a tiw administration versus DT prolonged time to CDMS and McDonald MS, and reduced overall MRI activity. Expand
Treatment effects of immunomodulatory therapies at different stages of multiple sclerosis in short-term trials
TLDR
Current evidence suggests that IFNβ therapy may be more effective in the early stages of SPMS, characterized by relapsing episodes and MRI evidence of greater brain lesion disease activity, and intervention with IFN β therapy is appropriate for all stages of MS except PPMS or non-relapsing SPMS. Expand
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