Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results.

  title={Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results.},
  author={F. Barkhof and C. Polman and E. Radue and L. Kappos and M. Freedman and G. Edan and H. Hartung and D. Miller and X. Montalban and Peter A. Poppe and M. de Vos and F. Lasri and L. Bauer and S. Dahms and K. Wagner and C. Pohl and R. Sandbrink},
  journal={Archives of neurology},
  volume={64 9},
  • F. Barkhof, C. Polman, +14 authors R. Sandbrink
  • Published 2007
  • Medicine
  • Archives of neurology
  • BACKGROUND In the Betaseron/Betaferon in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT) study, interferon beta-1b delayed conversion to multiple sclerosis in patients with a first clinical event and at least 2 clinically silent brain magnetic resonance imaging (MRI) lesions. OBJECTIVE To examine detailed MRI findings from the first 2 years of this trial. DESIGN Double-blind, placebo-controlled, randomized, parallel-group, multicenter, phase 3 study. SETTING Ninety-eight… CONTINUE READING
    48 Citations

    Tables and Topics from this paper

    Magnetic resonance imaging predictors of conversion to multiple sclerosis in the BENEFIT study.
    • 31
    • PDF
    MRI outcomes with cladribine tablets for multiple sclerosis in the CLARITY study
    • 29
    • 39
    MRI monitoring of immunomodulation in relapse-onset multiple sclerosis trials
    • 63


    Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group.
    • 1,438
    • PDF
    Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes.
    • 467
    • PDF
    Using gadolinium‐enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis
    • 338
    Limited duration of the effect of methylprednisolone on changes on MRI in multiple sclerosis
    • 36