Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results.
@article{Barkhof2007MagneticRI, title={Magnetic resonance imaging effects of interferon beta-1b in the BENEFIT study: integrated 2-year results.}, author={F. Barkhof and C. Polman and E. Radue and L. Kappos and M. Freedman and G. Edan and H. Hartung and D. Miller and X. Montalban and Peter A. Poppe and M. de Vos and F. Lasri and L. Bauer and S. Dahms and K. Wagner and C. Pohl and R. Sandbrink}, journal={Archives of neurology}, year={2007}, volume={64 9}, pages={ 1292-8 } }
BACKGROUND
In the Betaseron/Betaferon in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT) study, interferon beta-1b delayed conversion to multiple sclerosis in patients with a first clinical event and at least 2 clinically silent brain magnetic resonance imaging (MRI) lesions.
OBJECTIVE
To examine detailed MRI findings from the first 2 years of this trial.
DESIGN
Double-blind, placebo-controlled, randomized, parallel-group, multicenter, phase 3 study.
SETTING
Ninety-eight… CONTINUE READING
Supplemental Clinical Trials
Interventional Clinical Trial
This study will primarily compare the long-term effects of an early and continued treatment
with Betaferon/Betaseron (patients who were treated with active medication during the… Expand
Conditions | Multiple Sclerosis |
---|---|
Intervention | Drug |
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References
SHOWING 1-10 OF 28 REFERENCES
Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
- Medicine
- The Lancet
- 2001
- 1,002
Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group.
- Medicine
- The New England journal of medicine
- 2000
- 1,438
- PDF
Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis
- Medicine
- Neurology
- 1993
- 1,875
- PDF
Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes.
- Medicine
- Neurology
- 2006
- 467
- PDF
Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial
- Medicine
- The Lancet
- 2004
- 241
T(1) hypointense lesions in secondary progressive multiple sclerosis: effect of interferon beta-1b treatment.
- Medicine
- Brain : a journal of neurology
- 2001
- 99
- PDF
Using gadolinium‐enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis
- Medicine
- Annals of neurology
- 1992
- 338
Limited duration of the effect of methylprednisolone on changes on MRI in multiple sclerosis
- Medicine
- Neuroradiology
- 2004
- 36