Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice.

@article{Luo2010MagneticRI,
  title={Magnetic resonance imaging detection and time course of cerebral microhemorrhages during passive immunotherapy in living amyloid precursor protein transgenic mice.},
  author={Feng E. Luo and Nathan R. Rustay and Terese Seifert and Beate Roesner and Vincent P. Hradil and Heinz Hillen and Ulrich Ebert and Jean M. Severin and Bryan F. Cox and Daniel A. Llano and Mark Day and Gerard B. Fox},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={335 3},
  pages={
          580-8
        }
}
In recent years immunotherapy-based approaches for treating Alzheimer's disease have become the subject of intensive research. However, an important mechanistic-related safety concern is exacerbation of the risk of microhemorrhage that may be associated with fast removal of amyloid-β (Aβ) deposits found in blood vessels or brain parenchyma. Rapid in vivo detection of microhemorrhages in living amyloid precursor protein transgenic mice has not been described, and histological analysis can take… CONTINUE READING

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