Magnetic resonance imaging demonstrates differential atrophy of pontine base and tegmentum in Machado-Joseph disease.

Abstract

The pons is one of the brain areas demonstrating selective degeneration in Machado-Joseph disease (MJD), which is caused by the expansion of a polyglutamine stretch in the protein called ataxin-3. Although the resultant pontine atrophy is readily recognized by magnetic resonance imaging (MRI), the features and natural process of atrophy are not fully… (More)

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