Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents

@inproceedings{Magnin2015MagneticRM,
  title={Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents},
  author={R{\'e}mi Magnin and Fabien Rabusseau and Fr{\'e}d{\'e}ric Salabartan and Sebastien M{\'e}riaux and Jean-François Aubry and Denis Le Bihan and Erik Dumont and Beno{\^i}t Larrat},
  booktitle={Journal of therapeutic ultrasound},
  year={2015}
}
BACKGROUND Focused ultrasound combined with microbubble injection is capable of locally and transiently enhancing the permeability of the blood-brain barrier (BBB). Magnetic resonance imaging (MRI) guidance enables to plan, monitor, and characterize the BBB disruption. Being able to precisely and remotely control the permeabilization location is of great interest to perform reproducible drug delivery protocols. METHODS In this study, we developed an MR-guided motorized focused ultrasound (FUS… CONTINUE READING
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