Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study.

@article{Kim2016MagneticRE,
  title={Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study.},
  author={R G Kim and Phirum Nguyen and Ricki Bettencourt and Parambir S Dulai and William M Haufe and Jonathan C Hooker and Jeet Minocha and Mark A Valasek and Hamed Aryafar and David Allen Brenner and Claude B. Sirlin and Rohit Loomba},
  journal={Alimentary pharmacology & therapeutics},
  year={2016},
  volume={44 3},
  pages={
          287-99
        }
}
BACKGROUND Limited data exist on the clinical presentation and non-invasive detection of liver fibrosis in adults with homozygous Z genotype alpha-1 antitrypsin (AAT) deficiency. AIMS To compare demographic, biochemical, histological and imaging data of AAT deficient patients to normal-control and biopsy-proven non-alcoholic fatty liver disease (NAFLD) patients, and to assess the diagnostic accuracy of magnetic resonance elastography (MRE) in detecting fibrosis in AAT deficiency. METHODS… CONTINUE READING
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