Magnetic particle motions within living cells. Measurement of cytoplasmic viscosity and motile activity.

@article{Valberg1987MagneticPM,
  title={Magnetic particle motions within living cells. Measurement of cytoplasmic viscosity and motile activity.},
  author={Peter A. Valberg and Hume A. Feldman},
  journal={Biophysical journal},
  year={1987},
  volume={52 4},
  pages={551-61}
}
Submicrometer magnetic particles, ingested by cells and monitored via the magnetic fields they generate, provide an alternative to optical microscopy for probing movement and viscosity of living cytoplasm, and can be used for cells both in vitro and in vivo. We present methods for preparing lung macrophages tagged with magnetic particles for magnetometric study. Interpretation of the data involves fitting experimental remanent-field decay curves to nonlinear mechanistic models of intracellular… CONTINUE READING