Magnetic-Resonance-Imaging Texture Analysis Predicts Early Progression in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiation

@article{Nardone2019MagneticResonanceImagingTA,
  title={Magnetic-Resonance-Imaging Texture Analysis Predicts Early Progression in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiation},
  author={Valerio Nardone and Alfonso Reginelli and Fernando Scala and Salvatore Francesco Carbone and Maria Antonietta Mazzei and Lucio Sebaste and Tommaso Carfagno and Giuseppe Battaglia and Pierpaolo Pastina and Pierpaolo Correale and Paolo Tini and Gianluca Pellino and Salvatore Cappabianca and Luigi Pirtoli},
  journal={Gastroenterology Research and Practice},
  year={2019},
  volume={2019}
}
Background We hypothesized that texture analysis (TA) from the preoperative MRI can predict early disease progression (ePD), defined as the percentage of patients who relapsed or showed distant metastasis within three months from the radical surgery, in patients with locally advanced rectal cancer (LARC, stage II and III, AJCC) undergoing neoadjuvant chemoradiotherapy (C-RT). Methods This retrospective monoinstitutional cohort study included 49 consecutive patients in total with a newly… 

Figures and Tables from this paper

MRI features and texture analysis for the early prediction of therapeutic response to neoadjuvant chemoradiotherapy and tumor recurrence of locally advanced rectal cancer
TLDR
Imaging features and texture parameters of T2-weighted MR images of rectal cancer can help to predict treatment response and the risk for tumor recurrence and could be valuable for predicting the treatment response to nCRT.
18F-FDG-PET/MRI texture analysis in rectal cancer after neoadjuvant chemoradiotherapy
TLDR
PET/MRI texture analysis seems to represent a valuable tool in the identification of rectal cancer patients with a complete pathological response to nCRT among patients undergoing curative-intent surgery.
MRI T2-weighted sequences-based texture analysis (TA) as a predictor of response to neoadjuvant chemo-radiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC)
TLDR
MRI T2-weighted sequences-based TA was not effective in predicting pathological complete response to nCRT in patients with LARC, and further studies are needed to thoroughly investigate the potential of MRI TA in this setting.
Role of CT texture analysis for predicting peritoneal metastases in patients with gastric cancer
TLDR
The preliminary results suggest the potential value of CT texture analysis for predicting the risk of PM from GC, which may be helpful to stratify patients and address them to the most appropriate treatment.
Does restaging MRI radiomics analysis improve pathological complete response prediction in rectal cancer patients? A prognostic model development
TLDR
Radiomics analysis showed good performance in identifying complete responders, which increased when combined with standard clinical evaluation; this increase was not statistically significant but did improve the prediction of clinical response.
A field strength independent MR radiomics model to predict pathological complete response in locally advanced rectal cancer
TLDR
The generalised radiomics model developed showed good performance, even when data from patients scanned on 1.5 T and 3 T were merged, and shows that magnetic field intensity variability can be overcome by means of selecting appropriate image features.
Response prediction of neoadjuvant chemoradiation therapy in locally advanced rectal cancer using CT-based fractal dimension analysis
TLDR
Fractal dimension analysis on pretreatment CT was associated with response to neo-adjuvant chemoradiation in patients with locally advanced rectal cancer and is a promising biomarker for predicting pCR to nCRT and may potentially select patients for individualized therapy.
Ability of Delta Radiomics to Predict a Complete Pathological Response in Patients with Loco-Regional Rectal Cancer Addressed to Neoadjuvant Chemo-Radiation and Surgery
TLDR
It is found that D-TA may really predict the frequency of pCR in this patient setting and, thus, it may be investigated as a potential item to identify candidate patients who may benefit from an aggressive radical surgery.
Endorectal Ultrasound and Magnetic Resonance Imaging for Rectal Cancer Staging: A Modern Multimodality Approach
TLDR
This study investigated the diagnostic performance of conventional MRI alone, in combination with the DWI technique and ERUS in order to assess the best diagnostic imaging combination for rectal cancer staging.
Delta-radiomics and response to neoadjuvant treatment in locally advanced gastric cancer-a multicenter study of GIRCG (Italian Research Group for Gastric Cancer).
TLDR
Investigation of the reliability of computed tomography texture analysis in predicting the histo-pathological response to NAC in patients with resectable locally advanced gastric cancer finds post-NAC GLCM contrast and dissimilarity and delta G LCM contrast TA parameters seem to be reliable for identifying patients with locally AGC responder to Nac.
...
...

References

SHOWING 1-10 OF 31 REFERENCES
Texture Analysis as Imaging Biomarker of Tumoral Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients Studied with 3-T Magnetic Resonance
TLDR
Texture parameters derived from T2w images of rectal cancer have the potential to act as imaging biomarkers of tumoral response to neoadjuvant CRT.
Performance of diffusion-weighted imaging, perfusion imaging, and texture analysis in predicting tumoral response to neoadjuvant chemoradiotherapy in rectal cancer patients studied with 3T MR: initial experience
TLDR
Pre-treatment kurtosis derived from T2w images and Ve from pMRI have the potential to act as imaging biomarkers of rectal cancer response to neoadjuvant CRT.
Rectal Cancer: Assessment of Neoadjuvant Chemoradiation Outcome based on Radiomics of Multiparametric MRI
TLDR
Through a systematic analysis of multiparametric MR imaging features, the authors are able to build models with improved predictive value over conventional imaging metrics, suggesting the wealth of imaging radiomics should be further explored to help tailoring the treatment into the era of personalized medicine.
Preoperative magnetic resonance imaging assessment of circumferential resection margin predicts disease-free survival and local recurrence: 5-year follow-up results of the MERCURY study.
  • F. Taylor, P. Quirke, Gina Brown
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2014
TLDR
High-resolution MRI preoperative assessment of CRM status is superior to AJCC TNM-based criteria for assessing risk of LR, DFS, and OS; therefore, colorectal cancer teams could intensify treatment and follow-up accordingly to improve survival outcomes.
Rectal carcinoma: thin-section MR imaging for staging in 28 patients.
TLDR
Preoperative thin-section MR imaging accurately indicates the tumor stage of rectal cancer and depth of extramural tumor infiltration and provides valuable information for identifying T3 tumors for preoperative adjuvant therapy in patients who are at high risk of failure of complete excision.
The use of personalized biomarkers and liquid biopsies to monitor treatment response and disease recurrence in locally advanced rectal cancer after neoadjuvant chemoradiation
TLDR
This study supports the use of personalized biomarkers and liquid biopsies to tailor the management of rectal cancer patients, however, replication in a larger cohort is necessary to introduce this strategy into clinical practice.
Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer.
TLDR
Compared to preoperative RT alone, preoperative CRT enhances pathological response and improves local control in resectable stage II and III rectal cancer, but does not benefit disease free or overall survival.
...
...