Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.

  title={Magnetic Nanosensors for the Detection of Oligonucleotide Sequences.},
  author={Lee Josephson and J. Manuel Perez and Ralph Weissleder},
  journal={Angewandte Chemie},
  volume={40 17},
Superparamagnetic nanoparticles conjugated to oligonucleotides exert sensitive and reversible effects on the spin-spin relaxation rates of adjacent water protons when the conjugates hybridize to target oligonucleotides (see temperature cycle in the picture). The fluid-phase magnetic sensors provide the basis for detecting specific nucleic acid sequences in turbid media and potentially in tissues in vivo. 

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