Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption.

Abstract

Magnetic Fe(3)O(4)@mesoporous silica (MS) composites were synthesized by generating Fe(3)O(4) nanoparticles in the mesoporous silica matrix using the sol-gel method in nitrogen atmosphere. The mesoporous silica hosts include SBA-15 particles owning highly ordered p6mm mesostructure, siliceous mesostructured cellular foams (MCFs), and fiber-like mesoporous silica (FMS) with unique pore structures. The X-ray diffraction (XRD), transmission electron microscopy (TEM), and N(2) adsorption/desorption results show that Fe(3)O(4) functionalized MCFs and FMS possess suitable mesoporous structure for the adsorption of both small-molecular drug and large biomolecules. The biocompatibility tests on L929 fibroblast cells using MTT assay reveal low cytotoxicity of these systems. These Fe(3)O(4)@mesoporous silica composites show sustained release properties for aspirin in vitro. The release of the aspirin molecules from the pores of the Fe(3)O(4)@mesoporous silica composites is basically a diffusive process. Fe(3)O(4)@MCFs and Fe(3)O(4)@FMS owning larger pore size are good candidates for the adsorption of bovine serum albumin (BSA). These magnetic composites can be potential vectors for drug delivery and bioadsorption.

DOI: 10.1016/j.jcis.2012.02.031
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@article{Huang2012MagneticFS, title={Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption.}, author={Shanshan Huang and Chunxia Li and Ziyong Cheng and Yong Fan and Piaoping Yang and Cuimiao Zhang and Kuiyue Yang and Julie Qiaojin Lin}, journal={Journal of colloid and interface science}, year={2012}, volume={376 1}, pages={312-21} }