Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant rats.

@article{Euser2008MagnesiumST,
  title={Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant rats.},
  author={Anna Gerrit Euser and Lisa V Bullinger and Marilyn J. Cipolla},
  journal={Experimental physiology},
  year={2008},
  volume={93 2},
  pages={254-61}
}
Eclampsia is associated with increased blood-brain barrier (BBB) permeability and formation of cerebral oedema. Magnesium sulphate is used to treat eclampsia despite an unclear mechanism of action. This study was to determine the effect of magnesium sulphate on in vivo BBB permeability and formation of cerebral oedema during acute hypertension and on brain aquaporin-4 (AQP4) protein expression. An in vivo model of hypertensive encephalopathy was used in late-pregnant (LP) rats following… CONTINUE READING