Magnesium sulphate reduces cell volume in physiological conditions but not in the cytotoxic oedema during global brain ischemia.

@article{Chacn2006MagnesiumSR,
  title={Magnesium sulphate reduces cell volume in physiological conditions but not in the cytotoxic oedema during global brain ischemia.},
  author={Andrea Chac{\'o}n and Elena Lisott and Antonio Eblen-Zajjur},
  journal={Brain injury},
  year={2006},
  volume={20 10},
  pages={1087-91}
}
PRIMARY OBJECTIVE To establish the effect of MgSO4 on brain cellular volume during physiological and global ischemia using impedanciometric method. RESEARCH DESIGN Impedanciometric measure in the brain before and during global brain ischemia, with or without intravenous infusion of MgSO4. METHODS AND PROCEDURES Male Sprague-Dawley rats were anaesthetized (thiobarbital, 60 mg kg-1 i.p.). Ringer solution (n=9) or MgSO4 (n=8; 1 mmol Kg-1) where i.v. isovolumetrically administered. Sub-cortical… CONTINUE READING