Magnesium sulphate for preventing preterm birth in threatened preterm labour.

@article{Crowther2002MagnesiumSF,
  title={Magnesium sulphate for preventing preterm birth in threatened preterm labour.},
  author={Caroline A. Crowther and Janet E. Hiller and Lex William Doyle},
  journal={The Cochrane database of systematic reviews},
  year={2002},
  volume={4},
  pages={
          CD001060
        }
}
BACKGROUND Magnesium sulphate is used to inhibit uterine activity in women in preterm labour to prevent preterm birth. [] Key MethodSEARCH STRATEGY We searched the Cochrane Pregnancy and Childbirth Group trials register (May 2002) and the Cochrane Controlled Trials Register (The Cochrane Library, Issue 2, 2002). SELECTION CRITERIA TYPES OF PARTICIPANTS Women thought to be in preterm labour.
Magnesium sulphate for preventing preterm birth in threatened preterm labour.
TLDR
Magnesium sulphate is ineffective at delaying birth or preventing preterm birth, has no apparent advantages for a range of neonatal and maternal outcomes as a tocolytic agent, and its use for this indication may be associated with an increased risk of total fetal and maternal deaths.
Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour.
TLDR
There is not enough evidence to show any difference between magnesium maintenance therapy compared with either placebo or no treatment, or alternative therapies (ritodrine or terbutaline) in preventing preterm birth after an episode of threatened preterm labour.
Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour.
TLDR
There is insufficient evidence to support the use of oxytocin receptor antagonists to inhibit preterm birth after a period of threatened or actual preterm labour.
Oxytocin receptor antagonists for inhibiting preterm labour.
TLDR
This review failed to demonstrate the superiority of atosiban over betamimetics or placebo in terms of tocolytic efficacy or infant outcomes, and suggests that calcium channel blockers (mainly nifedipine) are associated with better neonatal outcome and fewer maternal side-effects than betamicetics.
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
TLDR
The role for antenatal magnesium sulphate therapy as a neuroprotective agent for the preterm fetus is not yet established and outcomes later in childhood should be evaluated to determine the presence or absence of later potentially important neurologic effects, particularly on motor or cognitive function.
Magnesium sulphate for women at term for neuroprotection of the fetus.
TLDR
There is currently insufficient evidence to assess the efficacy and safety of magnesium sulphate when administered to women for neuroprotection of the term fetus, and high-quality randomised controlled trials are needed to determine the safety profile and neurological outcomes for theterm fetus.
Betamimetics for inhibiting preterm labour.
TLDR
Betamimetics help to delay birth, which may give time to allow women to be transferred to tertiary care or to complete a course of antenatal corticosteroids, however, multiple adverse effects must be considered.
Relaxin for preventing preterm birth.
TLDR
There is limited randomised controlled trial evidence available on the effect of relaxin during pregnancy for preventing preterm birth for women in preterm labour, and none of the three included trials found significant differences in the outcomes of fetal death, neonatal death, birthweight or pretermBirth.
Different magnesium sulphate regimens for neuroprotection of the fetus for women at risk of preterm birth.
TLDR
Strong evidence supports the use of antenatal magnesium sulphate for neuroprotection of the fetus prior to very preterm birth, and research should be directed towards comparisons of different dosages and other variations in regimens, evaluating both maternal and infant outcomes.
A review of the role for magnesium sulphate in preterm labour
TLDR
It is possible, on the other hand, that the prophylactic administration of much lower dosages of MgSO4, in selected cases of preterm labour, may have a neuroprotective effect for a small number of infants.
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TLDR
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TLDR
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