Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania.

@article{Barbosa2011MagnesiumSA,
  title={Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania.},
  author={Francisco Jaime Barbosa and Bernardete Hesse and Rodrigo Bonifx00E1cio de Almeida and Irin{\'e}ia Paulina Baretta and Roseli Boerngen-Lacerda and Roberto Andreatini},
  journal={Pharmacological reports : PR},
  year={2011},
  volume={63 1},
  pages={64-70}
}
Magnesium sulfate (MgSO4) is used to treat and prevent eclamptic seizures, and several anticonvulsant drugs (e.g., sodium valproate) are clinically effective antimanic drugs. Psychostimulant-induced hyperlocomotion has been proposed as an animal model for the study of antimanic drugs. The present study evaluated the effects of MgSO4 and sodium valproate (as a positive control) on hyperlocomotion induced by methylphenidate in mice. Acute MgSO4 (300-400 mg/kg), but not sodium valproate (100-300… CONTINUE READING

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