Magnesium sulfate: rationale for its use in preeclampsia.

  title={Magnesium sulfate: rationale for its use in preeclampsia.},
  author={Kathleen V. Watson and Charles F. Moldow and Paul L. Ogburn and Harry S. Jacob},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 4},
Preeclampsia is a disorder of pregnancy characterized clinically by hypertension, proteinuria, and edema and characterized pathologically in its late stages by widespread microvascular thrombi. There is evidence from a number of studies that production of prostacyclin (prostaglandin I2, PGI2), a potent vasodilator and inhibitor of platelet aggregation, is deficient in preeclamptic compared to normal pregnancy. Traditional therapy utilizes infusions of large amounts of MgSO4, but the physiologic… CONTINUE READING


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