Magnesium reverses inhibitory effects of calcium deprivation on coordinate response of 3T3 cells to serum.


Deprivation of Ca(2+) in crowded cultures of 3T3 cells inhibits the onset of DNA synthesis. By raising [Mg(2+)] to 15 mM the inhibition produced by Ca(2+) deprivation can be fully overcome. Sparse cultures are not inhibited by a similar deprivation of Ca(2+), and therefore are not stimulated by supranormal [Mg(2+)]. The time course of stimulation of the… (More)

7 Figures and Tables


  • Presentations referencing similar topics