Magnesium protects against cisplatin-induced acute kidney injury without compromising cisplatin-mediated killing of an ovarian tumor xenograft in mice.

@article{Solanki2015MagnesiumPA,
  title={Magnesium protects against cisplatin-induced acute kidney injury without compromising cisplatin-mediated killing of an ovarian tumor xenograft in mice.},
  author={Malvika H Solanki and Prodyot K. Chatterjee and Xiangying Xue and Madhu Gupta and Ivy A. Rosales and Michael M Yeboah and Nina Kohn and Christine N Metz},
  journal={American journal of physiology. Renal physiology},
  year={2015},
  volume={309 1},
  pages={F35-47}
}
Cisplatin, a commonly used chemotherapeutic for ovarian and other cancers, leads to hypomagnesemia in most patients and causes acute kidney injury (AKI) in 25-30% of patients. Previously, we showed that magnesium deficiency worsens cisplatin-induced AKI and magnesium replacement during cisplatin treatment protects against cisplatin-mediated AKI in non-tumor-bearing mice (Solanki MH, Chatterjee PK, Gupta M, Xue X, Plagov A, Metz MH, Mintz R, Singhal PC, Metz CN. Am J Physiol Renal Physiol 307… CONTINUE READING
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