Magnesium magnetic isotope effect: A key to the mechanochemistry of phosphorylating enzymes as molecular machines

@article{Buchachenko2006MagnesiumMI,
  title={Magnesium magnetic isotope effect: A key to the mechanochemistry of phosphorylating enzymes as molecular machines},
  author={Anatoly Buchachenko and Denis A Kuznetsov},
  journal={Molecular Biology},
  year={2006},
  volume={40},
  pages={9-15}
}
The discovery of the powerful magnesium isotope effect on enzymatic ATP synthesis provides a new insight into the mechanochemistry of enzymes as molecular machines. The catalytic activities of ATPase, creatine kinase, and glycerophsphate kinase containing a Mg2+ ion with magnetic isotope nuclei (25Mg) were found to be two to four times higher than those of the enzymes with spinless, nonmagnetic magnesium cation isotopes (24Mg or 26Mg). This demonstrates unambiguously that ATP synthesis is a… CONTINUE READING
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