Magnesium lithospermate B decreases [Ca(2+)]i in endothelial cells by inhibiting K(+) currents.

Magnesium lithospermate B (MLB) is a hydrophilic active component of Salviae miltiorrhizae Radix. Studies have shown that MLB affected intracellular calcium ([Ca(2+)]i), but the underlying mechanism was unclear yet. The present work was aimed to investigate the underlying mechanism of MLB affecting [Ca(2+)]i in endothelial cells (ECs). Isolated mesentery… CONTINUE READING