Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP.

@article{Novgorodov1994MagnesiumIM,
  title={Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP.},
  author={Sergei A. Novgorodov and Tatyana I. Gudz and Gerald P. Brierley and Douglas R. Pfeiffer},
  journal={Archives of biochemistry and biophysics},
  year={1994},
  volume={311 2},
  pages={
          219-28
        }
}
Regulation of the mitochondrial permeability transition pore has been investigated following the release of matrix solutes which normally participate in pore regulation. Under these conditions, neither cyclosporin A nor ADP induces pore closure, as judged by restoration of delta psi, unless Mg2+ is also added. Mg2+ alone is ineffective. In liver mitochondria, the Mg2+ effect is expressed over a 0 to 0.5 mM concentration range with higher concentrations inhibiting repolarization. In heart… CONTINUE READING
Highly Cited
This paper has 27 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1996
View 12 Excerpts
Highly Influenced