Magnesium ion catalyzed P-N bond hydrolysis in imidazolide activated nucleotides. Relevance to template-directed synthesis of polynucleotides

@article{Kanavarioti2006MagnesiumIC,
  title={Magnesium ion catalyzed P-N bond hydrolysis in imidazolide activated nucleotides. Relevance to template-directed synthesis of polynucleotides},
  author={A. Kanavarioti and C. F. Bernasconi and D. L. Doodokyan and D. Alberas},
  journal={Origins of life and evolution of the biosphere},
  year={2006},
  volume={19},
  pages={353}
}
Magnesium, an ion necessary in enzymatic as well as in nonenzymatic template-directed polynucleotide-synthesizing reactions, has been found to catalyze the hydroxide ion attack on the P-N bond of selected 5'-monophosphate imidazolide derivatives of nucleotides, such as guanosine 5'-monophosphate 2-methylimidazolide (2-MeImpG), guanosine 5'-monophosphate imidazolide (ImpG), and adenosine 5-monophosphate 2-methylimidazolide (2-MeImpA). Calcium ion behaves similarly, but quantitatively the effects… Expand
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References

Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model.